How do telomeres and NHEJ coexist?
نویسنده
چکیده
The telomeres of eukaryotes are stable open double-strand ends that coexist with nonhomologous end joining (NHEJ), the repair pathway that directly ligates DNA ends generated by double-strand breaks. Since a single end-joining event between 2 telomeres generates a circular chromosome or an unstable dicentric chromosome, NHEJ must be prevented from acting on telomeres. Multiple mechanisms mediated by telomere factors act in synergy to achieve this inhibition.
منابع مشابه
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014